Yes. Some sites don't even specify what's on-topic and what not. In the end, all that matters is that there are users willing to vote to close the question; if it's 'slightly' off-topic but interesting enough, a question might stay open.
(By off-topic I mean not even related to that which is on-topic.)
That's unlikely to happen and usually a sign that 1) the site doesn't have enough active moderation (by ♦ moderators and high-level users) or 2) you have a different interpretation of what's mentioned in the Help Center than the community.